Phenylboronic acid Chemical Properties,Uses,Production
white to light yellow crystal powder
Reagent used for• ;Rhodium-catalyzed intramolecular amination1 • ;Pd-catalyzed direct arylation2 • ;Mizoroki-Heck and Suzuki-Miyaura coupling reactions catalyzed by palladium nanoparticles3 • ;Palladium-catalyzed stereoselective Heck-type reaction4 • ;Highly effective Palladium-catalyzed arylation Suzuki-Miyaura cross-coupling in water5 Reagent used in Preparation of• ;Ni(II) pincer complex and Pd(II) pyridoxal hydrazone metallacycles as catalysts for the Suzuki-Miyaura cross-coupling reactions6,7• ;N-type polymers for all-polymer solar cells8 •
Phenylboronic Acid is a compound used in organic synthesis of various pharmaceutical goods.
Phenyihoronic acid and its derivatives form complexes with polyol compounds such as saccharides and poly(vinyl alcohol) (PVA). Glucose-sensitive hydrogels can be prepared by using phenylhoronic acid as a ligand for target glucose. For example. a copolymer with phenylboronic acid moieties was synthesized by copolymerization of 4V-vinyl-2-pyrrolidone (NVP) and 3-(acryl- amide)phcnylhoronic acid (PBA). The complexes between the NVP-PBA copolymer and PVA enable us to construct glucose-sensitive insulin release systems because the complexes dissociated in response to the glucose concentration. This phenylboronic acid is soluble in water and the coupling reaction can even be carried out in water. It is compatible with many organic substituents such as esters, ketones, alcohols, etc. which would prohibit the use of Grignard reagents in coupling reactions.
This arylboronic acid (FW = 121.93 g/mol; CAS 98-80-6), also known as
benzeneboronic acid, phenylboric acid, and phenylboron dihydroxide,
inhibits a number of serine-dependent enzymes. Note: Commercial sources
typically contain varying amounts of phenylboronic anhydride, and
prolonged storage results in the formation of significant amounts of
phenylboroxide. Target (s) : aminoacylase; Aspergillus melleus semi-
alkaline protease, identical or closely related to oryzin; bacterial leucyl
aminopeptidase; cholesterol esterase, or sterol esterase, Ki = 36 μM (3-
5,23); chymotrypsin; cutinase; diacylglycerol lipase; b-
lactamase; lecithin:cholesterol acyltransferase, or LCAT; lipase, or
triacylglycerol lipase; lipoprotein lipas; oryzin; pancreatic
elastase; peptidyltransferase; serine-type D-Ala-D-Ala
carboxypeptidase; subtilisin; Treponema denticola protease
; and urease, weakly inhibited.
Phenylboronic acid Preparation Products And Raw materials